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New DNA ‘Cutting’ Technology May Be a Path to HIV Cure

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www.advocate.com

may be the next step to curing HIV: literally cutting the virus from an individual’s DNA where it has incorporated itself into the genome.

This “excision” is accomplished through the use of lipid nanoparticle-delivered CRISPR-Cas9. For those unfamiliar with this technology, CRISPR-Cas9 is e­ffectively a biological “machine” that allows for the cutting and removal of specific sections of DNA.

The lipid nanoparticle (or LNP) serves as a means of delivering CRISPR-Cas9 to the DNA so it can enter and begin cutting away the virus.In simpler terms, think of the CRISPR-Cas9 as a pair of scissors.

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